Combined analysis of resting-state fMRI and DTI data reveals abnormal development of function-structure in early-onset schizophrenia

Authors:
Ming Ke;Xing Huang;Hui Shen;Zongtan Zhou;Xiaogang Chen;Dewen Hu
Affiliations:
Lanzhou University of Technology, Lanzhou, P.R. China and College of Mechatronics and Automation, National University of Defense Technology, Changsha, P.R. China;College of Mechatronics and Automation, National University of Defense Technology, Changsha, P.R. China;College of Mechatronics and Automation, National University of Defense Technology, Changsha, P.R. China;College of Mechatronics and Automation, National University of Defense Technology, Changsha, P.R. China;The Second Xiangya Hospital, Center South University, Changsha, P.R. China;College of Mechatronics and Automation, National University of Defense Technology, Changsha, P.R. China and National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal Universit ...
Venue:
RSKT'08 Proceedings of the 3rd international conference on Rough sets and knowledge technology
Year:
2008

Citing 1
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Abstract

A combined analysis by integrating the resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) is presented in this paper to investigate the structure-function relationship in early-onset schizophrenia. After fractional anisotropy in white matter was assessed, functional connectivity was analyzed with regions of reference which was defined according to the regions showed lower fractional anisotropy values. We found significant decreased functional connectivity in early-onset schizophrenia correlated with the regions of anisotropy changes. Our results demonstrated that the white matter lesions may disrupt the anatomical connectivity and inflect the functional connectivity between the frontal regions and other brain regions.