Glycobrowser: a tool for contextual visualization of biological data and pathways using ontologies

  • Authors:

  • Matthew Eavenson;Maciej Janik;Shravya Nimmagadda;John A. Miller;Krys J. Kochut;William S. York

  • Affiliations:

  • Computer Science Department, University of Georgia, Athens, GA;Computer Science Department, University of Georgia, Athens, GA;Computer Science Department, University of Georgia, Athens, GA;Computer Science Department, University of Georgia, Athens, GA;Computer Science Department, University of Georgia, Athens, GA;Complex Carbohydrate Research Center, University of Georgia, Athens, GA

  • Venue:
  • ISBRA'08 Proceedings of the 4th international conference on Bioinformatics research and applications
  • Year:
  • 2008

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Abstract

This paper introduces GlycoBrowser, a dynamic biological pathwayexploration and visualization tool. Its capabilities include incremental navigationof pathways, as well as overlaying relevant experimental data about glycans andreactions within a pathway. The use of ontologies not only allows dynamic constructionof pathways, but also facilitates more accurate validation of the informationretrieved. Pathway exploration is initiated by means of an ontologicallydriven glycan structure building tool, which facilitates glycan structure constructionand searching with minimal user error. Because of the complex nature ofglycan structures and the difficulty involved in interpreting the associated data,GlycoBrowser is tailored especially to suit the needs of glycobiologists.