Genetic programming: on the programming of computers by means of natural selection
Genetic programming: on the programming of computers by means of natural selection
Genetic programming II: automatic discovery of reusable programs
Genetic programming II: automatic discovery of reusable programs
Genetic programming: an introduction: on the automatic evolution of computer programs and its applications
Foundations of genetic programming
Foundations of genetic programming
Understanding the Crucial Role of AttributeInteraction in Data Mining
Artificial Intelligence Review
Genetic Programming and Data Structures: Genetic Programming + Data Structures = Automatic Programming!
Genetic Programming III: Darwinian Invention & Problem Solving
Genetic Programming III: Darwinian Invention & Problem Solving
Data Mining and Knowledge Discovery with Evolutionary Algorithms
Data Mining and Knowledge Discovery with Evolutionary Algorithms
Genetic Programming IV: Routine Human-Competitive Machine Intelligence
Genetic Programming IV: Routine Human-Competitive Machine Intelligence
Evolutionary Computation
Genetic Programming Theory and Practice III (Genetic Programming)
Genetic Programming Theory and Practice III (Genetic Programming)
PRIB'07 Proceedings of the 2nd IAPR international conference on Pattern recognition in bioinformatics
Exploiting expert knowledge in genetic programming for genome-wide genetic analysis
PPSN'06 Proceedings of the 9th international conference on Parallel Problem Solving from Nature
Proceedings of the 11th Annual conference on Genetic and evolutionary computation
CEC'09 Proceedings of the Eleventh conference on Congress on Evolutionary Computation
Open issues in genetic programming
Genetic Programming and Evolvable Machines
Incorporating domain knowledge into evolutionary computing for discovering gene-gene interaction
PPSN'10 Proceedings of the 11th international conference on Parallel problem solving from nature: Part I
PRIB'10 Proceedings of the 5th IAPR international conference on Pattern recognition in bioinformatics
ECAL'09 Proceedings of the 10th European conference on Advances in artificial life: Darwin meets von Neumann - Volume Part I
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An important goal of human genetics is to identify DNA sequence variations that are predictive of susceptibility to common human diseases. This is a classification problem with data consisting of discrete attributes and a binary outcome. A variety of different machine learning methods based on artificial evolution have been developed and applied to modeling the relationship between genotype and phenotype. While artificial evolution approaches show promise, they are far from perfect and are only loosely based on real biological and evolutionary processes. It has recently been suggested that a new paradigm is needed where "artificial evolution" is transformed to "computational evolution" (CE) by incorporating more biological and evolutionary complexity into existing algorithms. It has been proposed that CE systems will be more likely to solve problems of interest to biologists and biomedical researchers. The goal of the present study was to develop and evaluate a prototype CE system for the analysis of human genetics data. We describe here this new open-ended CE system and provide initial results from a simulation study that suggests more complex operators result in better solutions.