From digital genetics to knowledge discovery: Perspectives in genetic network understanding

  • Authors:
  • Guillaume Beslon;David P. Parsons;Jose-María Peña;Christophe Rigotti;Yolanda Sanchez-Dehesa

  • Affiliations:
  • (Correspd. E-mail: guillaume.beslon@liris.cnrs.fr) Université de Lyon, CNRS, INSA-Lyon, LIRIS, UMR5205, F-69621, France and IXXI, Institut Rhône-Alpin des Systèmes Complexes, Lyon, ...;Université de Lyon, CNRS, INSA-Lyon, LIRIS, UMR5205, F-69621, France and IXXI, Institut Rhône-Alpin des Systèmes Complexes, Lyon, F-69007, France;DATSI, Universidad Politecnica de Madrid, Spain;Université de Lyon, CNRS, INSA-Lyon, LIRIS, UMR5205, F-69621, France and IXXI, Institut Rhône-Alpin des Systèmes Complexes, Lyon, F-69007, France;Université de Lyon, CNRS, INSA-Lyon, LIRIS, UMR5205, F-69621, France and IXXI, Institut Rhône-Alpin des Systèmes Complexes, Lyon, F-69007, France

  • Venue:
  • Intelligent Data Analysis - Knowledge Discovery in Bioinformatics
  • Year:
  • 2010

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Abstract

In this paper, we propose an original computational approach to assist knowledge discovery in complex biological networks. First, we present an integrated model of the evolution of regulation networks that can be used to uncover organization principles of such networks. Then, we propose to use the results of our model as a benchmark for knowledge discovery algorithms. We describe a first experiment of such benchmarking by using gene knock-out data generated from the modeled organisms.