Spectrum fusion: using multiple mass spectra for de novo peptide sequencing

Authors:
Ritendra Datta;Marshall Bern
Affiliations:
Penn State University, University Park, PA;Palo Alto Research Center, Palo Alto, CA
Venue:
RECOMB'08 Proceedings of the 12th annual international conference on Research in computational molecular biology
Year:
2008

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Abstract

We report on a new algorithm for combining the information from several mass spectra of the same peptide. The algorithm automatically learns peptide fragmentation patterns, so that it can handle spectra from any instrument and fragmentation technique. We demonstrate the utility of the algorithm, and the power of multiple spectra, by showing that combining pairs of spectra (one CID and one ETD) greatly improves de novo sequencing success rates.