Toward principles for the design of ontologies used for knowledge sharing
International Journal of Human-Computer Studies - Special issue: the role of formal ontology in the information technology
From concepts to clinical reality: an essay on the benchmarking of biomedical terminologies
Journal of Biomedical Informatics - Special issue: Biomedical ontologies
yOWL: An ontology-driven knowledge base for yeast biologists
Journal of Biomedical Informatics
GFO-Bio: A biological core ontology
Applied Ontology - Towards a Metaontology for the Biomedical Domain
A realism-based analysis of the OpenEHR entry model
Proceedings of the first international workshop on Managing interoperability and complexity in health systems
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Science aims to develop an accurate understanding of reality through a variety of rigorously empirical and formal methods. Ontologies are used to formalize the meaning of terms within a domain of discourse. The Basic Formal Ontology (BFO) is an ontology of particular importance in the biomedical domains, where it provides the top-level for numerous ontologies, including those admitted as part of the OBO Foundry collection. The BFO requires that all classes in an ontology are actually instantiated in reality. Despite the fact that it is hard to show whether entities of some kind exist or do not exist in reality (especially for unobservable entities like elementary particles), this criterion fails to satisfy the need of scientists to communicate their findings and theories unambiguously. We discuss the problems that arise due to the BFO's realism criterion and suggest viable alternatives.