Modelling and analysis of gene regulatory network using feedback control theory

  • Authors:

  • H. El-Samad;M. Khammash

  • Affiliations:

  • Department of Mechanical Engineering, University of California at Santa Barbara, Santa Barbara, CA 93106, USA;Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA

  • Venue:
  • International Journal of Systems Science - Dynamics Analysis of Gene Regulatory Networks
  • Year:
  • 2010

Quantified Score

Hi-index 0.00

Visualization

Abstract

Molecular pathways are a part of a remarkable hierarchy of regulatory networks that operate at all levels of organisation. These regulatory networks are responsible for much of the biological complexity within the cell. The dynamic character of these pathways and the prevalence of feedback regulation strategies in their operation make them amenable to systematic mathematical analysis using the same tools that have been used with success in analysing and designing engineering control systems. In this article, we aim at establishing this strong connection through various examples where the behaviour exhibited by gene networks is explained in terms of their underlying control strategies. We complement our analysis by a survey of mathematical techniques commonly used to model gene regulatory networks and analyse their dynamic behaviour.