Constructing majority-rule supertrees

  • Authors:
  • Jianrong Dong;David Fernández-Baca;F. R. McMorris

  • Affiliations:
  • Department of Computer Science, Iowa State University, Ames, IA;Department of Computer Science, Iowa State University, Ames, IA;Department of Applied Mathematics, Illinois Institute of Technology, Chicago, IL

  • Venue:
  • WABI'09 Proceedings of the 9th international conference on Algorithms in bioinformatics
  • Year:
  • 2009

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Abstract

Supertree methods combine the phylogenetic information from multiple partially-overlapping trees into a larger phylogenetic tree called a supertree. Several supertree construction methods have been proposed to date, but most of these are not designed with any specific properties in mind. Recently, Cotton and Wilkinson proposed extensions of the majority-rule consensus tree method to the supertree setting that inherit many of the appealing properties of the former. Here we study a variant of one of their methods, called majority-rule (+) supertrees. After proving that a key underlying problem for constructing majority-rule (+) supertrees is NP-hard, we develop a polynomial-size integer linear programming formulation of the problem.We then report on a preliminary computational study of our approach. The results indicate that our method is computationally feasible for moderately large inputs. Perhaps more significantly, our results suggest that the majority-rule (+) approach produces biologically meaningful results.