Solving the DNA fragment assembly problem efficiently using iterative optimization with evolved hypermutations

  • Authors:
  • Jiří Kubalik;Petr Buryan;Libor Wagner

  • Affiliations:
  • CTU Prague, Prague, Czech Rep;CTU Prague, Prague, Czech Rep;CTU Prague, Prague, Czech Rep

  • Venue:
  • Proceedings of the 12th annual conference on Genetic and evolutionary computation
  • Year:
  • 2010

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Abstract

The paper presents a successful application of an evolutionary based iterative optimization method called Prototype Optimization with Evolved Improvement Steps (POEMS) to the DNA fragment assembly problem. The DNA fragment assembly problem, known to be NP-hard, is of great importance as it constitutes an important step in the genome project. The POEMS is an iterative algorithm that employs an evolutionary algorithm for exploration of the current solution's neighborhood in each iteration of the optimization process. Experiments show that the proposed POEMS approach performs very well and generates better results than those generated by other state-of-the-art methods.