Foundations of statistical natural language processing
Foundations of statistical natural language processing
Proceedings of the 5th International Conference on Intelligent Systems for Molecular Biology
Augmenting SSEs with Structural Properties for Rapid Protein Structure Comparison
BIBE '03 Proceedings of the 3rd IEEE Symposium on BioInformatics and BioEngineering
A hybrid approach for indexing and searching protein structures
WSEAS Transactions on Computers
PADS: protein structure alignment using directional shape signatures
DASFAA'05 Proceedings of the 10th international conference on Database Systems for Advanced Applications
Computers in Biology and Medicine
Hi-index | 0.00 |
Within this paper, a novel strategy for structural alignment of proteins based on text modeling techniques is introduced. The method summarizes the protein secondary and tertiary structure in two textual sequences. The first sequence is used to initial superposition of secondary structure elements and the second sequence is employed to align the 3D-structure of two compared structures. The comparison technique used by the method has been inspired from computational linguistics for analysing and quantifying textual sequences. In this strategy, the cross-entropy measure over n-gram models is used to capture regularities between sequences of protein structures. The performance of the method is evaluated and compared with CE and SSM methods. The results of the experiments reported here provide evidence for the preference and applicability of the new approach in terms of efficiency and effectiveness.