Inference with constrained hidden markov models in prism

  • Authors:
  • Henning Christiansen;Christian theil Have;Ole torp Lassen;Matthieu Petit

  • Affiliations:
  • Research group plis: programming, logic and intelligent systems, department of communication, business and information technologies, roskilde university, p.o.box 260, dk-4000 roskilde, denmark (e- ...;Research group plis: programming, logic and intelligent systems, department of communication, business and information technologies, roskilde university, p.o.box 260, dk-4000 roskilde, denmark (e- ...;Research group plis: programming, logic and intelligent systems, department of communication, business and information technologies, roskilde university, p.o.box 260, dk-4000 roskilde, denmark (e- ...;Research group plis: programming, logic and intelligent systems, department of communication, business and information technologies, roskilde university, p.o.box 260, dk-4000 roskilde, denmark (e- ...

  • Venue:
  • Theory and Practice of Logic Programming
  • Year:
  • 2010

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Abstract

A Hidden Markov Model (HMM) is a common statistical model which is widely used for analysis of biological sequence data and other sequential phenomena. In the present paper we show how HMMs can be extended with side-constraints and present constraint solving techniques for efficient inference. Defining HMMs with side-constraints in Constraint Logic Programming has advantages in terms of more compact expression and pruning opportunities during inference. We present a PRISM-based framework for extending HMMs with side-constraints and show how well-known constraints such as cardinality and all_different are integrated. We experimentally validate our approach on the biologically motivated problem of global pairwise alignment.