C4.5: programs for machine learning
C4.5: programs for machine learning
Solving the multiple instance problem with axis-parallel rectangles
Artificial Intelligence
A framework for multiple-instance learning
NIPS '97 Proceedings of the 1997 conference on Advances in neural information processing systems 10
Data mining: practical machine learning tools and techniques with Java implementations
Data mining: practical machine learning tools and techniques with Java implementations
An Intelligent System for Vertebrate Promoter Recognition
IEEE Intelligent Systems
ICDM '04 Proceedings of the Fourth IEEE International Conference on Data Mining
MILES: Multiple-Instance Learning via Embedded Instance Selection
IEEE Transactions on Pattern Analysis and Machine Intelligence
Motif Discovery as a Multiple-Instance Problem
ICTAI '06 Proceedings of the 18th IEEE International Conference on Tools with Artificial Intelligence
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Core promoters are crucial regions for initiation of gene transcription. Identification of core promoters is important to the understanding of transcriptional regulation and elucidation of relationships among genes of an organism. Experimentally locating core promoters is laborious and costly. Therefore, it is desirable to develop computational approaches to support and complement experimental methods. However, computational prediction of core promoters of eukaryotic species is challenging. In this paper, we first formulate the core promoter prediction problem as a variation of the multiple instance learning problem. We then develop a new algorithm for identifying core promoters with a high positive prediction rate and a high sensitivity. Since many computational biology problems can be formulated under the multiple instance learning paradigm, our approach may inspire future research of applying multiple instance learning techniques to complex biology problems and our method may have broad potential applications.