Automated quantification and analysis of mandibular asymmetry

Authors:
Tron A. Darvann;Nuno V. Hermann;Per Larsen;Hildur Ólafsdóttir;Izabella V. Hansen;Hanne D. Hove;Leif Christensen;Daniel Rueckert;Sven Kreiborg
Affiliations:
3D Craniofacial Image Research Laboratory, Copenhagen University Hospital Rigshospitalet, School of Dentistry, University of Copenhagen, and DTU Informatics, Technical University of Denmark, Copen ...;3D Craniofacial Image Res. Lab., Copenhagen Univ. Hospital Rigshospitalet, Sch. of Dentistry, Univ. of Copenhagen, and DTU Inf., Techn. Univ. of Denmark, and Pediatric Dentistry and Clinical Genet ...;3D Craniofacial Image Research Laboratory, Copenhagen University Hospital Rigshospitalet, School of Dentistry, University of Copenhagen, and DTU Informatics, Technical University of Denmark, Copen ...;DTU Informatics, Technical University of Denmark, Lyngby, Denmark;Orthodontics, School of Dentistry, University of Copenhagen, Copenhagen, Denmark;Department of Clinical Genetics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark;Department of Neurosurgery, Århus University Hospital, Århus, Denmark;Visual Information Processing, Department of Computing, Imperial College London, London, UK;3D Craniofacial Image Res. Lab., Copenhagen Univ. Hosp. Rigshospitalet, Sch. of Dentistry, Univ. of Copenhagen, and DTU Inf., Techn. Univ. of Denmark and Pediatric Dentistry and Clinical Genetics ...
Venue:
ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
Year:
2010

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Abstract

We present an automated method of spatially detailed 3D asymmetry quantification in mandibles extracted from CT and apply it to a population of infants with unilateral coronal synostosis (UCS). An atlas-based method employing nonrigid registration of surfaces is used for determining deformation fields, thereby establishing detailed anatomical point correspondence between subjects as well as between points on the left and right side of the mid-sagittal plane (MSP). Asymmetry is defined in terms of the vector between a point and the corresponding anatomical point on the opposite side of the MSP after mirroring the mandible across the MSP. A principal components analysis of asymmetry characterizes the major types of asymmetry in the population, and successfully separates the asymmetric UCS mandibles from a number of less asymmetric mandibles from a control population.