A priori guided reconstruction for FDOT using mixed norms

Authors:
Jean-Charles Baritaux;Michael Unser
Affiliations:
Biomedical Imaging Lab., Swiss Institute of Technology, Lausanne;Biomedical Imaging Lab., Swiss Institute of Technology, Lausanne
Venue:
ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
Year:
2010

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Abstract

We propose new soft-prior approach for incorporating structural a priori in FDOT reconstruction. The technique is a non-linear regularization scheme based on the penalization of the (2, 1)-mixed norm. We solve the numerical reconstruction problem with an iterative thresholding-type algorithm. We present simulation results that demonstrate an improvement both in resolution and fluorophore concentration estimation, compared to prior-free approaches.