MR contrast synthesis for lesion segmentation

  • Authors:
  • Snehashis Roy;Aaron Carass;Navid Shiee;Dzung L. Pham;Jerry L. Prince

  • Affiliations:
  • Image Analysis and Communications Laboratory, Electrical and Computer Engineering, The Johns Hopkins University;Image Analysis and Communications Laboratory, Electrical and Computer Engineering, The Johns Hopkins University;Image Analysis and Communications Laboratory, Electrical and Computer Engineering, The Johns Hopkins University;MedIC, Neuroradiology Division, Radiology and Radiological Science, The Johns Hopkins University;Image Analysis and Communications Laboratory, Electrical and Computer Engineering, The Johns Hopkins University

  • Venue:
  • ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
  • Year:
  • 2010

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Abstract

The magnetic resonance contrast of a neuroimaging data set has strong impact on the utility of the data in image analysis tasks, such as registration and segmentation. Lengthy acquisition times often prevent routine acquisition of multiple MR contrast images, and opportunities for detailed analysis using these data would seem to be irrevocably lost. This paper describes an example based approach which uses patch matching from a multiple contrast atlas with the intended goal of generating an alternate MR contrast image, thus effectively simulating alternative pulse sequences from one another. In this paper, we deal specifically with Fluid Attenuated Inversion Recovery (FLAIR) sequence generation from Tl and T2 pulse sequences. The applicability of this synthetic FLAIR for estimating white matter lesions segmentation is demonstrated.