MRI-based prostate brachytherapy seed localization

  • Authors:

  • Nathanael Kuo;Junghoon Lee;Clare Tempany;Matthias Stuber;Jerry Prince

  • Affiliations:

  • Johns Hopkins University, Baltimore, MD and Departments of Brigham and Women's Hospital, Boston., MA;Johns Hopkins University, Baltimore, MD and Departments of Electrical and Computer Engineering, Brigham and Women's Hospital, Boston, MA and Departments of Radiology, Brigham and Women's Hospital, ...;Johns Hopkins University, Baltimore, MD and Departments of Radiology;Johns Hopkins University, Baltimore, MD and Departments of Electrical and Computer Engineering, Brigham and Women's Hospital, Boston, MA;Johns Hopkins University, Baltimore, MD and Departments of Brigham and Women's Hospital, Boston, MA

  • Venue:
  • ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
  • Year:
  • 2010

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Abstract

A magnetic resonance imaging (MRI) pulse sequence and a corresponding image processing algorithm to localize prostate brachy-therapy seeds during or after therapy are presented. Inversion-Recovery with ON-resonant water suppression (IRON) is an MRI methodology that generates positive contrast in regions of magnetic field susceptibility, as created by prostate brachytherapy seeds. Phantoms comprising of several materials found in brachytherapy seeds were created to assess the usability of the IRON pulse sequence for imaging seeds. Resulting images show that seed materials are clearly visible with high contrast using IRON, agreeing with theoretical predictions. A seed localization algorithm to process IRON images demonstrates the potential of this imaging technique for seed localization and dosimetry.