CAM: A web tool for combining array CGH and microarray gene expression data from multiple samples

Authors:
Mira Oh;Bongjun Song;Hyunju Lee
Affiliations:
Department of Information and Communications, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea;Department of Information and Communications, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea;Department of Information and Communications, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea
Venue:
Computers in Biology and Medicine
Year:
2010

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Abstract

We develop a web-based tool for Combining Array CGH copy number aberration data and Microarray gene expression data (CAM). This tool analyzes these two data sets from multiple samples to detect genes having both DNA copy number aberrations (CNAs) and gene expression changes. CAM provides several statistical methods for identifying CNAs, which are consistent across multiple samples. Identified CNAs and their correlated gene expression changes are then visualized along the chromosomes. As a result, CAM is a useful tool for identifying disease related genes when these two types of data sets are available. To illustrate the various analysis outputs of CAM, we subsequently provide ten sets of example data from seven cancer types.