Automating extraction and analysis of dopaminergic axon terminals in images of frontal slices of the striatum

Authors:
I. B. Gurevich;E. A. Kozina;A. A. Myagkov;M. V. Ugryumov;V. V. Yashina
Affiliations:
Dorodnicyn Computing Centre, Russian Academy of Sciences, Moscow, Russia 119333;Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia 119334;Dorodnicyn Computing Centre, Russian Academy of Sciences, Moscow, Russia 119333;Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia 119334;Dorodnicyn Computing Centre, Russian Academy of Sciences, Moscow, Russia 119333
Venue:
Pattern Recognition and Image Analysis
Year:
2010

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Abstract

We develop a method to automate the obtaining of experimental data necessary to supplement the model of the preclinical stage of Parkinson's disease. As a source of experimental data for constructing the model, images of stained slices of the brains of experimental animals are used. The suggested method is based on mathematical morphology operations and intended for automatic extraction of dopaminergic neuron terminals in images of frontal slices of the striatum. Experimental studies have confirmed the possibility and expediency of automating the processing and analysis of images of slices using this method.