Wavelet-based image registration and segmentation framework for the quantitative evaluation of hydrocephalus

  • Authors:
  • Fan Luo;Jeanette W. Evans;Norma C. Linney;Matthias H. Schmidt;Peter H. Gregson

  • Affiliations:
  • Mathematics and Computing Science Department, Saint Mary's University, Halifax, NS, Canada;Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada;Mathematics and Computing Science Department, Saint Mary's University, Halifax, NS, Canada;Department of Radiology, Dalhousie University, Halifax, NS, Canada;Electrical & Computer Engineering, Faculty of Engineering, Dalhousie University, Halifax, NS, Canada

  • Venue:
  • Journal of Biomedical Imaging
  • Year:
  • 2010

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Abstract

Hydrocephalus, characterized by increased fluid in the cerebral ventricles, is traditionally evaluated by a visual assessment of serial CT scans. The complex shape of the ventricular system makes accurate visual comparison of CT scans difficult. The current research developed a quantitative method to measure the change in cerebral ventricular volume over time. Key elements of the developed framework are: adaptive image registration based on mutual information and wavelet multiresolution analysis; adaptive segmentation with novel feature extraction based on the Dual-Tree Complex Wavelet Transform; volume calculation. The framework, when tested on physical phantoms, had an error of 2.3%. When validated on clinical cases, results showed that cases deemed to be normal/stable had a calculated volume change less than 5%. Those with progressive/treated hydrocephalus had a calculated change greater than 20%. These findings indicate that the framework is reasonable and has potential for development as a tool in the evaluation of hydrocephalus.