Study on photon transport problem based on the platform of molecular optical simulation environment

  • Authors:

  • Kuan Peng;Xinbo Gao;Jimin Liang;Xiaochao Qu;Nunu Ren;Xueli Chen;Bin Ma;Jie Tian

  • Affiliations:

  • School of Electronic Engineering, Xidian University, Xi'an, Shaanxi, China and Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China;School of Electronic Engineering, Xidian University, Xi'an, Shaanxi, China;Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China;Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China;School of Electronic Engineering, Xidian University, Xi'an, Shaanxi, China and Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China;School of Electronic Engineering, Xidian University, Xi'an, Shaanxi, China and Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China;Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China;Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China and Institute of Automation, Chinese Academy of Sciences, Beijing, China

  • Venue:
  • Journal of Biomedical Imaging - Special issue on mathematical methods for images and surfaces
  • Year:
  • 2010

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Abstract

As an important molecular imaging modality, optical imaging has attracted increasing attention in the recent years. Since the physical experiment is usually complicated and expensive, research methods based on simulation platforms have obtained extensive attention. We developed a simulation platform named Molecular Optical Simulation Environment (MOSE) to simulate photon transport in both biological tissues and free space for optical imaging based on noncontact measurement. In this platform, Monte Carlo (MC) method and the hybrid radiosity-radiance theorem are used to simulate photon transport in biological tissues and free space, respectively, so both contact and noncontact measurement modes of optical imaging can be simulated properly. In addition, a parallelization strategy for MC method is employed to improve the computational efficiency. In this paper, we study the photon transport problems in both biological tissues and free space using MOSE. The results are compared with Tracepro, simplified spherical harmonics method (SPn), and physical measurement to verify the performance of our study method on both accuracy and efficiency.