Detection of DTI White Matter Abnormalities in Multiple Sclerosis Patients
MICCAI '08 Proceedings of the 11th international conference on Medical Image Computing and Computer-Assisted Intervention - Part I
Septal Flash Assessment on CRT Candidates Based on Statistical Atlases of Motion
MICCAI '09 Proceedings of the 12th International Conference on Medical Image Computing and Computer-Assisted Intervention: Part II
Temporal diffeomorphic free-form deformation for strain quantification in 3D-US images
MICCAI'10 Proceedings of the 13th international conference on Medical image computing and computer-assisted intervention: Part II
Comparison of cardiac motion fields from tagged and untagged MR images using nonrigid registration
FIMH'05 Proceedings of the Third international conference on Functional Imaging and Modeling of the Heart
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In this paper, we present the use of atlas-based indexes of abnormality for the quantification of cardiac resynchronization therapy (CRT) outcome in terms of motion. We build an atlas of normal motion from 21 healthy volunteers to which we compare 88 CRT candidates before and after the therapy. Abnormal motion is quantified locally in time and space using a statistical distance to normality, and changes induced by the therapy are related with clinical measurements of CRT outcome. Results correlate with recent clinical hypothesis about CRT response, namely that the correction of specific mechanisms responsible for cardiac dyssynchrony conditions the response to the therapy.