Towards high-resolution cardiac atlases: ventricular anatomy descriptors for a standardized reference frame

  • Authors:
  • Ramón Casero;Rebecca A. B. Burton;T. Alexander Quinn;Christian Bollensdorff;Patrick Hales;Jürgen E. Schneider;Peter Kohl;Vicente Grau

  • Affiliations:
  • Computational Biology Group, Computing Laboratory, University of Oxford, Oxford, UK;Cardiac Mechano-Electric Feedback lab, Dept of Physiology, Anatomy and Genetics, University of Oxford, Oxford;Cardiac Mechano-Electric Feedback lab, Dept of Physiology, Anatomy and Genetics, University of Oxford, Oxford;Cardiac Mechano-Electric Feedback lab, Dept of Physiology, Anatomy and Genetics, University of Oxford, Oxford;Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;Cardiac Mechano-Electric Feedback lab, Dept of Physiology, Anatomy and Genetics, University of Oxford, Oxford;Institute of Biomedical Engineering, Dept of Engineering Science, and the Oxford e-Research Centre, University of Oxford, Oxford, UK

  • Venue:
  • STACOM'10/CESC'10 Proceedings of the First international conference on Statistical atlases and computational models of the heart, and international conference on Cardiac electrophysiological simulation challenge
  • Year:
  • 2010

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Abstract

Increased resolution in cardiac Magnetic Resonance Imaging (MRI) and growing interest in the effect of small structures in electrophysiology of the heart pose new challenges for cardiac atlases. In this paper we discuss the limitations of current atlas-building models when trying to incorporate cardiac small structure and argue for the need of developing a standard coordinate system for the heart that separates this from the macro-structure common to all individual hearts, in a way analogous to the stereotactic coordinate system from brain atlases. With this goal, we propose a set of methods to obtain two descriptors of the ventricular macro-structure that can be used to build a standardized reference frame: the central curve on the Left Ventricle cavity and the smoothed internal envelope of the Right Ventricle crest (i.e. the curve in the endocardial surface marking the junction between the right ventricular free wall and the septum).