Non-parametric diffeomorphic image registration with the demons algorithm
MICCAI'07 Proceedings of the 10th international conference on Medical image computing and computer-assisted intervention
Fast automatic multi-atlas segmentation of the prostate from 3D MR images
MICCAI'11 Proceedings of the 2011 international conference on Prostate cancer imaging: image analysis and image-guided interventions
Proceedings of the 4th International Symposium on Applied Sciences in Biomedical and Communication Technologies
Using ASM in CT data segmentaion for prostate radiotherapy
ICCVG'12 Proceedings of the 2012 international conference on Computer Vision and Graphics
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Prostate radiation therapy dose planning currently requires computed tomography (CT) scans as they contain electron density information needed for patient dose calculations. However magnetic resonance imaging (MRI) images have significantly superior soft-tissue contrast for segmenting organs of interest and determining the target volume for treatment. This paper describes work on the development of an alternative treatment workflow enabling both organ delineation and dose planning to be performed using MRI alone. This is achieved by atlas based segmentation and the generation of pseudo-CT scans from MRI. Planning and dosimetry results for three prostate cancer patients from Calvary Mater Newcastle Hospital (Australia) are presented supporting the feasibility of this workflow. Good DSC scores were found for the atlas based segmentation of the prostate (mean 0.84) and bones (mean 0.89). The agreement between MRI/pseudo-CT and CT planning was quantified by dose differences and distance to agreement in corresponding voxels. Dose differences were found to be less than 2%. Chi values indicate that the planning CT and pseudo-CT dose distributions are equivalent.