BlenX4Bio --- BlenX for Biologists
CMSB '09 Proceedings of the 7th International Conference on Computational Methods in Systems Biology
QEST '09 Proceedings of the 2009 Sixth International Conference on the Quantitative Evaluation of Systems
Hermes: agent-based middleware for mobile computing
SFM-Moby'05 Proceedings of the 5th international conference on Formal Methods for the Design of Computer, Communication, and Software Systems: mobile computing
A Uniform Multiscale Meta-model of BioShape
Electronic Notes in Theoretical Computer Science (ENTCS)
Towards Abstraction-Based Verification of Shape Calculus
Electronic Notes in Theoretical Computer Science (ENTCS)
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Many biological phenomena are inherently multiscale, i.e. they are characterised by interactions involving different scales at the same time. This is the case of bone remodelling, where macroscopic behaviour (at organ and tissue scale) and microstructure (at cell scale) strongly influence each other. Consequently, several approaches have been defined to model such a process at different spatial and temporal levels and, in particular, in terms of continuum properties, abstracting in this way from a realistic - and more complex - cellular scenario. While a large amount of information is available to validate such models separately, more work is needed to integrate all levels fully in a faithful multiscale model. In this scenario, we propose the use of BioShape, a 3D particle-based, scale-independent, geometry and space oriented simulator. It is used to define and integrate a cell and tissue scale model for bone remodelling in terms of shapes equipped with perception, interaction and movement capabilities. Their in-silico simulation allows for tuning continuum-based tissutal and cellular models, as well as for better understanding - both in qualitative and in quantitative terms - the blurry synergy between mechanical and metabolic factors triggering bone remodelling.