DNA library screening, pooling design and unitary spaces

Authors:
Suogang Gao;Zengti Li;Jiangchen Yu;Xiaofeng Gao;Weili Wu
Affiliations:
Mathematics and Information College, Hebei Normal University, Shijiazhuang 050016, China;Mathematics and Information College, Langfang Normal College, Langfang 065000, China;Department of Computer Science, University of Texas at Dallas, Richardson, TX 75080, USA;Department of Computer Science, University of Texas at Dallas, Richardson, TX 75080, USA;Department of Computer Science, University of Texas at Dallas, Richardson, TX 75080, USA
Venue:
Theoretical Computer Science
Year:
2011

Citing 4
Cited 1

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Discrete Mathematics
New constructions of non-adaptive and error-tolerance pooling designs

Discrete Mathematics
Pooling spaces associated with finite geometry

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Two constructions of new error-correcting pooling designs from orthogonal spaces over a finite field of characteristic 2

Journal of Combinatorial Optimization

Construction of error-tolerance pooling designs in symplectic spaces

Journal of Global Optimization

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Abstract

Pooling design is an important research topic in bio-informatics due to its wide applications in molecular biology, especially DNA library screening. In this paper, with unitary spaces over finite fields, we present two new constructions whose efficiency ratio, i.e., the ratio between the number of tests and the number of items, is smaller than some of the existing constructions.