MULTISCALE AGENT-BASED SIMULATION FOR CHONDROGENIC PATTERN FORMATION IN VITRO
Cybernetics and Systems
Multi-scale Modeling with Cellular Automata: The Complex Automata Approach
ACRI '08 Proceedings of the 8th international conference on Cellular Automata for Reseach and Industry
HYBRID SIMULATION ALGORITHMS FOR AN AGENT-BASED MODEL OF THE IMMUNE RESPONSE
Cybernetics and Systems - BEST OF AGENT-BASED MODELING AND SIMULATION 2008
Towards a Complex Automata Multiscale Model of In-Stent Restenosis
ICCS '09 Proceedings of the 9th International Conference on Computational Science: Part I
Hermes: agent-based middleware for mobile computing
SFM-Moby'05 Proceedings of the 5th international conference on Formal Methods for the Design of Computer, Communication, and Software Systems: mobile computing
Osteoporosis: a multiscale modeling viewpoint
Proceedings of the 9th International Conference on Computational Methods in Systems Biology
A Uniform Multiscale Meta-model of BioShape
Electronic Notes in Theoretical Computer Science (ENTCS)
Towards Abstraction-Based Verification of Shape Calculus
Electronic Notes in Theoretical Computer Science (ENTCS)
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Bone remodelling, as many biological phenomena, is inherently multi-scale, i.e. it is characterised by interactions involving different scales at the same time. At this aim, we exploit the Complex Automata paradigm and the BioShape 3D spatial simulator respectively (i) for describing the bone remodelling process in terms of a 2-scale aggregation of uniform Cellular Automata coupled by a well-established composition pattern, and (ii) for executing them in a uniform and integrated way in terms of shapes equipped with perception and movement capabilities. On the one hand, the proposed model confirms the high expressiveness degree of Complex Automata to describe multi-scale phenomena. On the other hand, the possibility of executing such a model in BIOSHAPE highlights the existence of a general mapping - from Complex Automata into the BIOSHAPE native modelling paradigm - also enforced by the fact that both approaches result to be suitable for handling different scales in a uniform way, for including spatial information and for bypassing inter-scale homogenization problems.