Automatic neuron tracing in volumetric microscopy images with anisotropic path searching

Authors:
Jun Xie;Ting Zhao;Tzumin Lee;Eugene Myers;Hanchuan Peng
Affiliations:
Howard Hughes Medical Institute, Ashburn, Virginia;Howard Hughes Medical Institute, Ashburn, Virginia;Howard Hughes Medical Institute, Ashburn, Virginia;Howard Hughes Medical Institute, Ashburn, Virginia;Howard Hughes Medical Institute, Ashburn, Virginia
Venue:
MICCAI'10 Proceedings of the 13th international conference on Medical image computing and computer-assisted intervention: Part II
Year:
2010

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Abstract

Full reconstruction of neuron morphology is of fundamental interest for the analysis and understanding of neuron function. We have developed a novel method capable of tracing neurons in threedimensional microscopy data automatically. In contrast to templatebased methods, the proposed approach makes no assumptions on the shape or appearance of neuron's body. Instead, an efficient seeding approach is applied to find significant pixels almost certainly within complex neuronal structures and the tracing problem is solved by computing an graph tree structure connecting these seeds. In addition, an automated neuron comparison method is introduced for performance evaluation and structure analysis. The proposed algorithm is computationally efficient. Experiments on different types of data show promising results.