Segmentation subject to stitching constraints: finding many small structures in a large image

  • Authors:
  • Elena Bernardis;Stellax X. Yu

  • Affiliations:
  • University of Pennsylvania, Philadelphia, PA;Boston College, Chestnut Hill, MA

  • Venue:
  • MICCAI'10 Proceedings of the 13th international conference on Medical image computing and computer-assisted intervention: Part I
  • Year:
  • 2010

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Abstract

Extracting numerous cells in a large microscopic image is often required in medical research. The challenge is to reduce the segmentation complexity on a large image without losing the fine segmentation granularity of small structures. We propose a constrained spectral graph partitioning approach where the segmentation of the entire image is obtained from a set of patch segmentations, independently derived but subject to stitching constraints between neighboring patches. The constraints come from mutual agreement analysis on patch segmentations from a previous round. Our experimental results demonstrate that the constrained segmentation not only stitches solutions seamlessly along overlapping patch borders but also refines the segmentation in the patch interiors.