Non-rigid registration with missing correspondences in preoperative and postresection brain images

  • Authors:
  • Nicha Chitphakdithai;James S. Duncan

  • Affiliations:
  • Biomedical Engineering;Biomedical Engineering and Electrical Engineering and Diagnostic Radiology, Yale University, New Haven, CT

  • Venue:
  • MICCAI'10 Proceedings of the 13th international conference on Medical image computing and computer-assisted intervention: Part I
  • Year:
  • 2010

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Abstract

Registration of preoperative and postresection images is often needed to evaluate the effectiveness of treatment. While several nonrigid registration methods exist, most would be unable to accurately align these types of datasets due to the absence of tissue in one image. Here we present a joint registration and segmentation algorithm which handles the missing correspondence problem. An intensity-based prior is used to aid in the segmentation of the resection region from voxels with valid correspondences in the two images. The problem is posed in a maximum a posteriori (MAP) framework and optimized using the expectation-maximization (EM) algorithm. Results on both synthetic and real data show our method improved image alignment compared to a traditional non-rigid registration algorithm as well as a method using a robust error kernel in the registration similarity metric.