Physically-Constrained Diffeomorphic Demons for the Estimation of 3D Myocardium Strain from Cine-MRI
FIMH '09 Proceedings of the 5th International Conference on Functional Imaging and Modeling of the Heart
Statistical analysis of the human cardiac fiber architecture from DT-MRI
FIMH'11 Proceedings of the 6th international conference on Functional imaging and modeling of the heart
FIMH'11 Proceedings of the 6th international conference on Functional imaging and modeling of the heart
Regionally optimised mathematical models of cardiac myocyte orientation in rat hearts
FIMH'11 Proceedings of the 6th international conference on Functional imaging and modeling of the heart
Automated personalised human left ventricular FE models to investigate heart failure mechanics
STACOM'12 Proceedings of the third international conference on Statistical Atlases and Computational Models of the Heart: imaging and modelling challenges
Patient-specific models of cardiac biomechanics
Journal of Computational Physics
A computational bilayer surface model of human atria
FIMH'13 Proceedings of the 7th international conference on Functional Imaging and Modeling of the Heart
Personalization of cardiac fiber orientations from image data using the unscented kalman filter
FIMH'13 Proceedings of the 7th international conference on Functional Imaging and Modeling of the Heart
Regional analysis of left ventricle function using a cardiac-specific polyaffine motion model
FIMH'13 Proceedings of the 7th international conference on Functional Imaging and Modeling of the Heart
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In vivo imaging of the cardiac 3D fibre architecture is still a challenge, but it would have many clinical applications, for instance to better understand pathologies and to follow up remodelling after therapy. Recently, cardiac MRI enabled the acquisition of Diffusion Tensor images (DTI) of 2D slices. We propose a method for the complete 3D reconstruction of cardiac fibre architecture in the left ventricular myocardium from sparse in vivo DTI slices. This is achieved in two steps. First we map non-linearly the left ventricular geometry to a truncated ellipsoid. Second, we express coordinates and tensor components in Prolate Spheroidal System, where an anisotropic Gaussian kernel regression interpolation is performed. The framework is initially applied to a statistical cardiac DTI atlas in order to estimate the optimal anisotropic bandwidths. Then, it is applied to in vivo beating heart DTI data sparsely acquired on a healthy subject. Resulting in vivo tensor field shows good correlation with literature, especially the elevation (helix) angle transmural variation. To our knowledge, this is the first reconstruction of in vivo human 3D cardiac fibre structure. Such approach opens up possibilities in terms of analysis of the fibre architecture in patients.