An introduction to variable and feature selection
The Journal of Machine Learning Research
Variable selection using svm based criteria
The Journal of Machine Learning Research
IEEE Transactions on Pattern Analysis and Machine Intelligence
On Classifying Disease-Induced Patterns in the Brain Using Diffusion Tensor Images
MICCAI '08 Proceedings of the 11th international conference on Medical Image Computing and Computer-Assisted Intervention - Part I
A Unified Framework for MR Based Disease Classification
IPMI '09 Proceedings of the 21st International Conference on Information Processing in Medical Imaging
International Journal of Imaging Systems and Technology
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HARDI based pattern classifiers for the identification of white matter pathologies
MICCAI'11 Proceedings of the 14th international conference on Medical image computing and computer-assisted intervention - Volume Part II
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The paper presents a method of creating abnormality classifiers learned from Diffusion Tensor Imaging (DTI) data of a population of patients and controls. The score produced by the classifier can be used to aid in diagnosis as it quantifies the degree of pathology. Using anatomically meaningful features computed from the DTI data we train a non-linear support vector machine (SVM) pattern classifier. The method begins with high dimensional elastic registration of DT images followed by a feature extraction step that involves creating a feature by concatenating average anisotropy and diffusivity values in anatomically meaningful regions. Feature selection is performed via a mutual information based technique followed by sequential elimination of the features. A non-linear SVM classifier is then constructed by training on the selected features. The classifier assigns each test subject with a probabilistic abnormality score that indicates the extent of pathology. In this study, abnormality classifiers were created for two populations; one consisting of schizophrenia patients (SCZ) and the other with individuals with autism spectrum disorder (ASD). A clear distinction between the SCZ patients and controls was achieved with 90.62% accuracy while for individuals with ASD, 89.58% classification accuracy was obtained. The abnormality scores clearly separate the groups and the high classification accuracy indicates the prospect of using the scores as a diagnostic and prognostic marker.