The grading of prostatic cancer in biopsy image based on two stages approach

  • Authors:
  • Shao-Kuo Tai;Cheng-Yi Li;Yee-Jee Jan;Shu-Chuan Lin

  • Affiliations:
  • Department of Information Management, Chaoyang University of Technology, Wufong Township Taichung County, Taiwan, R.O.C.;Department of Information Management, Chaoyang University of Technology, Wufong Township Taichung County, Taiwan, R.O.C.;Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.;Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.

  • Venue:
  • ICCCI'10 Proceedings of the Second international conference on Computational collective intelligence: technologies and applications - Volume Part II
  • Year:
  • 2010

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Abstract

Prostatic biopsies provide the information for the determined diagnosis of prostatic cancer. Computer-aid investigation of biopsies can reduce the loading of pathologists and also inter- and intra-observer variability as well. In this paper, we proposed a two stages approach for prostatic cancer grading according to Gleason grading system. The first stage classifies biopsy images into clusters based on their Skeleton-set (SK-set), so that images in the same cluster consist of the similar two-tone texture. In the second stage, we analyzed the fractal dimension of sub-bands derived from the images of prostatic biopsies. We adopted the Support Vector Machines as the classifier and using the leaving-one-out approach to estimate error rate. The present experimental results demonstrated that 92.1% of accuracy for a set of 1000 pathological prostatic biopsy images.