The nature of statistical learning theory
The nature of statistical learning theory
Principle of information diffusion
Fuzzy Sets and Systems
Utilize bootstrap in small data set learning for pilot run modeling of manufacturing systems
Expert Systems with Applications: An International Journal
Computers and Operations Research
A new approach for manufacturing forecast problems with insufficient data: the case of TFT---LCDs
Journal of Intelligent Manufacturing
Journal of Intelligent & Fuzzy Systems: Applications in Engineering and Technology - FUZZYSS'2011: 2nd International Fuzzy Systems Symposium
Hi-index | 12.05 |
Bladder cancer is a common urologic cancer. Radiotherapy plays an increasingly important role in treatment bladder cancer due to radiotherapy preserves normal bladder function. However, the five-year survival rate after radiotherapy for bladder cancer patients is 30-50%. Some biological proteins influence the outcome of radiotherapy. One or two specific proteins may not be sufficient to predict the effect of radiotherapy, analyzing multiple oncoproteins and tumor suppressor proteins may help the prediction. At present, no effective technique has been used to predict the outcome of radiotherapy by multiple protein expression file from a very limited number of patients. The bootstrap technique provides a new approach to improve the accuracy of prediction the outcome of radiotherapy in small dataset analysis. In this study, 13 proteins in each cell line from individual patient were measured and then cell viability was determined after cells irradiated with 5, 10, 20, or 30Gy of cobalt-60. The modeling results showed that when the number of training data increased, the learning accuracy of the prediction the outcome of radiotherapy was enhanced stably, from 55% to 85%. Using this technique to analyze the outcome of radiotherapy related to protein expression profile of individual cell line provides an example to help patients choosing radiotherapy for treatment.