Information Sciences: an International Journal
ProRank: a method for detecting protein complexes
Proceedings of the 14th annual conference on Genetic and evolutionary computation
Detecting protein complexes from noisy protein interaction data
Proceedings of the 11th International Workshop on Data Mining in Bioinformatics
Dense subgraph mining with a mixed graph model
Pattern Recognition Letters
| Hi-index | 3.84 |
Motivation: Advanced technologies are producing large-scale protein–protein interaction data at an ever increasing pace. A fundamental challenge in analyzing these data is the inference of protein machineries. Previous methods for detecting protein complexes have been mainly based on analyzing binary protein–protein interaction data, ignoring the more involved co-complex relations obtained from co-immunoprecipitation experiments. Results: Here, we devise a novel framework for protein complex detection from co-immunoprecipitation data. The framework aims at identifying sets of preys that significantly co-associate with the same set of baits. In application to an array of datasets from yeast, our method identifies thousands of protein complexes. Comparing these complexes to manually curated ones, we show that our method attains very high specificity and sensitivity levels (~ 80%), outperforming current approaches for protein complex inference. Availability: Supplementary information and the program are available at http://www.cs.tau.ac.il/~roded/CODEC/main.html. Contact: roded@post.tau.ac.il Supplementary information:Supplementary data are available at Bioinformatics online.