A renewable, modular, and time-responsive DNA circuit

Authors:
Ashish Goel;Morteza Ibrahimi
Affiliations:
Departments of Management Science and Engineering and (by courtesy) Computer Science, Stanford University, Stanford, USA;Departments of Electrical Engineering, Stanford University, Stanford, USA
Venue:
Natural Computing: an international journal
Year:
2011

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Abstract

In this article, we introduce a new design for DNA logic gates based on enzymatic restriction of DNA strands. We present a construction for a set of one and two-input logic gates and argue that our construction can be generalized to implement any Boolean operation. A key feature of our design is its time-responsiveness, in the presence of appropriate fuels our circuit can operate continuously and generate a time-dependent output in response to a time-dependent input. Moreover, modulo connectivity information, the strand design and circuit design phases are decoupled.