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The use of groups has had great success in medical and psychiatric contexts for over a century. Group interactions provide the critical social and emotional support that is frequently necessary for change and clinical improvement. In recent years, information technology has been used to enhance and extend traditional face-to-face group approaches. We describe three recent projects that use online group approaches and we discuss some of the opportunities and challenges that are part of this approach. Many medical conditions involve seniors, who are often computer novices, and so issues of usability, acceptance, and trust must be carefully and fully addressed by researchers and clinicians who wish to use online group approaches as part of their treatment model.