Implementing automatic spot addressing and contour based segmentation in microarray image analysis

Authors:
Alexandra Oliveros;Miguel Sotaquirá
Affiliations:
Electronic Engineering Department, Universidad del Norte, Colombia;Electronic Engineering Department, Universidad del Norte, Colombia
Venue:
BEBI'08 Proceedings of the 1st WSEAS international conference on Biomedical electronics and biomedical informatics
Year:
2008

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Abstract

DNA microarrays have become a widely used technique by geneticists to diagnose or treat diseases through gene expression. The process of analysis gene expression with DNA microarrays is based on the hybridization of a tissue's DNA sequence into a substrate and the further analysis of the image conformed by the genes in the DNA as green, red or yellow spots. The process of DNA microarray image analysis involves finding the location of the spots and the quantification of their expression level. In this paper, a tool designed to perform DNA microarray image analysis is described. Including the spot addressing based on the image projections, spot segmentation through contour based segmentation and the extraction genes expression relevant information.