On-line state estimation and identification of a fed-batch bioprocess

  • Authors:

  • Dan Selişteanu;Dorin Popescu;Cristina Barbu

  • Affiliations:

  • Department of Automatic Control, University of Craiova, Craiova;Department of Automatic Control, University of Craiova, Craiova;University "Spiru Haret" Craiova, Craiova, Romania

  • Venue:
  • MACMESE'07 Proceedings of the 9th WSEAS international conference on Mathematical and computational methods in science and engineering
  • Year:
  • 2007

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Abstract

This paper deals with the problem of on-line state estimation and identification for a fed-batch bioprocess, which is in fact a lipase production process that takes place inside a Fed-batch Bioreactor. The lipase production process is highly nonlinear and, furthermore, the available on-line measurements are lack and the reaction kinetics is not perfectly known. Some on-line state estimation strategies based on extended Luenberger observer and asymptotic observer approach are proposed. The unknown kinetic parameters of the bioprocess are estimated by using a distribution based identification technique. The performance of the proposed estimation strategies is analysed using numerical simulation.