Unbiased atlas formation via large deformations metric mapping

  • Authors:
  • Peter Lorenzen;Brad Davis;Sarang Joshi

  • Affiliations:
  • Department of Computer Science, Chapel Hill, NC;Department of Computer Science, Chapel Hill, NC;Department of Computer Science, Chapel Hill, NC and Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC

  • Venue:
  • MICCAI'05 Proceedings of the 8th international conference on Medical image computing and computer-assisted intervention - Volume Part II
  • Year:
  • 2005

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Abstract

The construction of population atlases is a key issue in medical image analysis, and particularly in brain mapping. Large sets of images are mapped into a common coordinate system to study intrapopulation variability and inter-population differences, to provide voxelwise mapping of functional sites, and to facilitate tissue and object segmentation via registration of anatomical labels. We formulate the unbiased atlas construction problem as a Fréchet mean estimation in the space of diffeomorphisms via large deformations metric mapping. A novel method for computing constant speed velocity fields and an analysis of atlas stability and robustness using entropy are presented. We address the question: how many images are required to build a stable brain atlas?