An inverse problem approach to the estimation of volume change

  • Authors:
  • Martin Schweiger;Oscar Camara-Rey;William R. Crum;Emma Lewis;Julia Schnabel;Simon R. Arridge;Derek L. G. Hill;Nick Fox

  • Affiliations:
  • Department of Computer Science, University College London;Centre for Medical Image Computing, University College London;Centre for Medical Image Computing, University College London;Centre for Medical Image Computing, University College London;Centre for Medical Image Computing, University College London;Department of Computer Science, University College London;Centre for Medical Image Computing, University College London;Dementia Research Centre, Institute of Neurology, University College London

  • Venue:
  • MICCAI'05 Proceedings of the 8th international conference on Medical image computing and computer-assisted intervention - Volume Part II
  • Year:
  • 2005

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Abstract

We present a new technique for determining structure-by-structure volume changes, using an inverse problem approach. Given a pre-labelled brain and a series of images at different time-points, we generate finite element meshes from the image data, with volume change modelled by means of an unknown coefficient of expansion on a perstructure basis. We can then determine the volume change in each structure of interest using inverse problem optimization techniques. The proposed method has been tested with simulated and clinical data. Results suggest that the presented technique can be seen as an alternative for volume change estimation.