Robust tissue boundary detection for cerebral cortical thickness estimation

  • Authors:
  • Marietta L. J. Scott;Neil A. Thacker

  • Affiliations:
  • University of Manchester, Manchester, UK;University of Manchester, Manchester, UK

  • Venue:
  • MICCAI'05 Proceedings of the 8th international conference on Medical image computing and computer-assisted intervention - Volume Part II
  • Year:
  • 2005

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Abstract

This paper presents an algorithm for determining regional cerebral grey matter cortical thickness from magnetic resonance scans. In particular, the modification of a gradient-based edge detector into an iso-grey-level boundary detector for reliably determining the low-contrast grey-white matter interface is described and discussed. The reproducibility of the algorithm over 31 gyral regions is assessed using repeat scans of four subjects, and a technique for correcting the misplacement of the grey-white matter boundary is shown to significantly reduce the systematic error on the reproducibility.