Adaptive neuro-fuzzy system as a novel approach for predicting post-dialysis urea rebound

Authors:
Ahmad Taher Azar
Affiliations:
Department of Electrical Communication and Electronics Systems Engineering, Modern Science and Arts University (MSA), 26 July Mehwar Road Intersection with Wahat Road, 6th of October City, ...
Venue:
International Journal of Intelligent Systems Technologies and Applications
Year:
2011

Citing 2
Cited 2

Neuro-fuzzy and soft computing: a computational approach to learning and machine intelligence

Neuro-fuzzy and soft computing: a computational approach to learning and machine intelligence
Soft computing for control of non-linear dynamical systems

Soft computing for control of non-linear dynamical systems

Multi-adaptive neural-fuzzy system as a novel predictor of in-vivo blood side dialyser urea clearance

International Journal of Computer Applications in Technology
Adaptive network based on fuzzy inference system for equilibrated urea concentration prediction

Computer Methods and Programs in Biomedicine

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Abstract

Total dialysis dose (Kt/V) is considered to be a major determinant of morbidity and mortality in haemodialysed patients. The continuous growth of the blood urea concentration over the 30-60-min period following dialysis, a phenomenon known as urea rebound, is a critical factor in determining the true dose of haemodialysis (HD). The misestimation of the equilibrated (true) post-dialysis blood urea or equilibrated Kt/V results in an inadequate HD prescription, with predictably poor clinical outcomes for the patients. The estimation of the equilibrated post-dialysis blood urea (Ceq) is therefore crucial in order to estimate the equilibrated (true) Kt/V. Measuring post-dialysis urea rebound (PDUR) requires a 30- or 60-min post-dialysis sampling, which is inconvenient. This paper presents a novel technique for predicting equilibrated urea concentration and PDUR in the form of a Takagi-Sugeno-Kang fuzzy inference system. The advantage of this neuro-fuzzy hybrid approach is that it does not require 30-60-min post-dialysis urea sample. Adaptive neuro-fuzzy inference system (ANFIS) was constructed to predict equilibrated urea (Ceq)taken at 60 min after the end of the HD session in order to predict PDUR. The accuracy of the ANFIS was prospectively compared with other traditional methods for predicting equilibrated urea (Ceq), PDUR and equilibrated dialysis dose (eqKt/V). The results are highly promising, and a comparative analysis suggests that the proposed modelling approach outperforms other traditional urea kinetic models.