An Improved Heuristic Algorithm for Finding Motif Signals in DNA Sequences

  • Authors:
  • Chao-Wen Huang;Wun-Shiun Lee;Sun-Yuan Hsieh

  • Affiliations:
  • National Cheng Kung University, Tainan;National Cheng Kung University, Tainan;National Cheng Kung University, Tainan

  • Venue:
  • IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
  • Year:
  • 2011

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Abstract

The planted (l,d)-motif search problem is a mathematical abstraction of the DNA functional site discovery task. In this paper, we propose a heuristic algorithm that can find planted (l,d)-signals in a given set of DNA sequences. Evaluations on simulated data sets demonstrate that the proposed algorithm outperforms current widely used motif finding algorithms. We also report the results of experiments on real biological data sets.