2011 Special Issue: How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models

Authors:
Bernd Porr;Lynsey McCabe;Paolo di Prodi;Christoph Kolodziejski;Florentin Wörgötter
Affiliations:
School of Engineering, University of Glasgow, G12 8QQ, United Kingdom;School of Engineering, University of Glasgow, G12 8QQ, United Kingdom;School of Engineering, University of Glasgow, G12 8QQ, United Kingdom;Bernstein Center for Computational Neuroscience, Göttingen, Germany and Department for Computational Neuroscience, III. Physikalisches Institut - Biophysik, Georg-August-University Götti ...;Bernstein Center for Computational Neuroscience, Göttingen, Germany and Department for Computational Neuroscience, III. Physikalisches Institut - Biophysik, Georg-August-University Götti ...
Venue:
Neural Networks
Year:
2011

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Abstract

It has been shown that plasticity is not a fixed property but, in fact, changes depending on the location of the synapse on the neuron and/or changes of biophysical parameters. Here, we investigate how plasticity is shaped by feedback inhibition in a cortical microcircuit. We use a differential Hebbian learning rule to model spike-timing-dependent plasticity and show analytically that the feedback inhibition shortens the time window for LTD during spike-timing-dependent plasticity but not for LTP. We then use a realistic GENESIS model to test two hypothesis about interneuron hypofunction and conclude that a reduction in GAD67 is the most likely candidate as the cause for hypofrontality as observed in Schizophrenia.