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In this paper, we present our Live Operational Intelligence (LOI) framework for developing, deploying, and executing applications that mine and analyze large amounts of data collected from multiple data sources to help operations staff take more informed decisions during management of operations in various industry verticals. We illustrate the use of the LOI framework with a case study from oil and gas drilling operations. The application involves characterizing and profiling on-shore wells being tapped for natural gas, and using this knowledge to construct a real-time operational intelligence engine for monitoring oil and gas drilling operations.