Support Vector Machines: Training and Applications
Support Vector Machines: Training and Applications
Gene Functional Annotation with Dynamic Hierarchical Classification Guided by Orthologs
DS '09 Proceedings of the 12th International Conference on Discovery Science
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In recent years, a number of machine learning approaches to literature-based gene function annotation have been proposed. However, due to issues such as lack of labeled data, class imbalance and computational cost, they have usually been unable to surpass simpler approaches based on string-matching. In this paper, we propose a principled machine learning approach based on kernel classifiers. We show that kernels can address the task's inherent data scarcity by embedding additional knowledge and we propose a simple yet effective solution to deal with class imbalance. From experiments on the TREC Genomics Track data, our approach achieves better F1-score than two state-of-the-art approaches based on string-matching and cross-species information.