Correlating clinical scores with anatomical electrodes locations for assessing deep brain stimulation

  • Authors:

  • Florent Lalys;Claire Haegelen;Alexandre Abadie;Pierre Jannin

  • Affiliations:

  • INSERM, U746, Faculty of Medicine CS 34317, Rennes, France and INRIA, VisAGeS Unit/Project, Rennes, France and University of Rennes I, CNRS, UMR 6074, IRISA, Rennes, France;INSERM, U746, Faculty of Medicine CS 34317, Rennes, France and INRIA, VisAGeS Unit/Project, Rennes, France and University of Rennes I, CNRS, UMR 6074, IRISA, Rennes, France and Department of Neuro ...;INSERM, U746, Faculty of Medicine CS 34317, Rennes, France and INRIA, VisAGeS Unit/Project, Rennes, France and University of Rennes I, CNRS, UMR 6074, IRISA, Rennes, France;INSERM, U746, Faculty of Medicine CS 34317, Rennes, France and INRIA, VisAGeS Unit/Project, Rennes, France and University of Rennes I, CNRS, UMR 6074, IRISA, Rennes, France

  • Venue:
  • IPCAI'11 Proceedings of the Second international conference on Information processing in computer-assisted interventions
  • Year:
  • 2011

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Abstract

Movement disorders in patients with Parkinson's disease may require functional surgery, when medical therapy isn't effective. In Deep Brain Stimulation (DBS), electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing digital atlases gathering patient's location of electrode contacts and clinical scores. Three motor and three neuro-psychological scores were integrated in the study. Correlations between active contacts localization and clinical data were carried out using an adapted Hierarchical Ascendant Classification and have enabled the extraction of clusters aiming to suggest optimum sites for therapeutic STN DBS. The postero-superior region has been found to be effective for motor score improvement whereas the antero-inferior region revealed noticeable neuro-psychological scores deterioration. Comparison with existing results has shown that such atlases are very promising for understanding phenomena better.