Prediction of functional associations between proteins by means of a cost-sensitive artificial neural network

Authors:
J. P. Florido;H. Pomares;I. Rojas;J. M. Urquiza;F. Ortuño
Affiliations:
Dept. of Computer Architecture and Computer Technology, CITIC-UGR, University of Granada, Spain;Dept. of Computer Architecture and Computer Technology, CITIC-UGR, University of Granada, Spain;Dept. of Computer Architecture and Computer Technology, CITIC-UGR, University of Granada, Spain;Dept. of Computer Architecture and Computer Technology, CITIC-UGR, University of Granada, Spain;Dept. of Computer Architecture and Computer Technology, CITIC-UGR, University of Granada, Spain
Venue:
IWANN'11 Proceedings of the 11th international conference on Artificial neural networks conference on Advances in computational intelligence - Volume Part II
Year:
2011

Citing 4
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Abstract

A challenge in systems biology is to discover new functional associations between proteins and, from these new relationships, assign functions to unannotated proteins. High-throughput data can be the key to achieve this task, but they often lack the degree of specificity needed for predicting accurate protein functional associations. This improvement in specificity can be achieved through the integration of heterogeneous data sets in a suitable manner. In this paper, we assess the quality of prediction of functional associations between proteins in two cases: (1) using each data source in isolation and (2) by means of Artificial Neural Networks through the integration of different biological data sources.