Exact computation of amplification for a class of nonlinear systems arising from cellular signaling pathways

  • Authors:
  • Eduardo D. Sontag;Madalena Chaves

  • Affiliations:
  • Department of Mathematics, Rutgers University, New Brunswick, NJ 08903, USA;Institute for Systems Theory and Automatic Control, University of Stuttgart, Pfaffenwaldring 9, 70550 Stuttgart, Germany

  • Venue:
  • Automatica (Journal of IFAC)
  • Year:
  • 2006

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Abstract

A commonly employed measure of the signal amplification properties of an input/output system is its induced L^2 norm, sometimes also known as H"~ gain. In general, however, it is extremely difficult to compute the numerical value for this norm, or even to check that it is finite, unless the system being studied is linear. This paper describes a class of systems for which it is possible to reduce this computation to that of finding the norm of an associated linear system. In contrast to linearization approaches, a precise value, not an estimate, is obtained for the full nonlinear model. The class of systems that we study arose from the modeling of certain biological intracellular signaling cascades, but the results should be of wider applicability.