Personalization of pictorial structures for anatomical landmark localization

  • Authors:
  • Vaclav Potesil;Timor Kadir;Günther Platsch;Sir Michael Brady

  • Affiliations:
  • Department of Engineering Science, University of Oxford and Siemens Molecular Imaging, Oxford, United Kingdom;Department of Engineering Science, University of Oxford and Mirada Medical, Oxford, United Kingdom;Siemens Molecular Imaging, Oxford, United Kingdom;Department of Radiation Oncology and Biology, University of Oxford

  • Venue:
  • IPMI'11 Proceedings of the 22nd international conference on Information processing in medical imaging
  • Year:
  • 2011

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Abstract

We propose a method for accurately localizing anatomical landmarks in 3D medical volumes based on dense matching of parts-based graphical models. Our novel approach replaces population mean models by jointly leveraging weighted combinations of labeled exemplars (both spatial and appearance) to obtain personalized models for the localization of arbitrary landmarks in upper body images. We compare the method to a baseline population-mean graphical model and atlas-based deformable registration optimized for CT-CT registration, by measuring the localization accuracy of 22 anatomical landmarks in clinical 3D CT volumes, using a database of 83 lung cancer patients. The average mean localization error across all landmarks is 2.35 voxels. Our proposed method outperforms deformable registration by 73%, 93% for the most improved landmark. Compared to the baseline population-mean graphical model, the average improvement of localization accuracy is 32%; 67% for the most improved landmark.